Maesteg have a lead of 12 on try-count, but only have three matches remaining compared to the six due for Llanharan, who are nine points adrift.
Whitland look almost sure to finish third and they are at Treorchy, while Narberth face a trick challenge at the Memorial Ground against in-form Glamorgan Wanderers, who produced a splendid midweek win over UWIC by 45-30.
Rumney hope to gain a win at home to struggling Tondu and Beddau would dearly like to take the points at home to Carmarthen Athletic and UWIC hope to put out a stronger side home to Llangennech, while Bonymaen coach Matt McCarthy will take his revitalised youngster to Brynmawr in search of a fifth successive victory.