And in two all Premier Division clashes, Bedwas are home to Newport and Cardiff travel to Aberavon.
But Tondu, who won 16-15 at Old Illtydians in Round 4, have the most demanding away day challenge against the Principality Premier Division second placed club who eased through to the last 16 with 31-14 home win over Caerphilly.
Aberavon – who knocked out defending champions Llandovery last weekend – have been rewarded with that home tie while Tonmawr, the Division One West leaders, will look forward to welcoming Premier Division leaders Neath.
Pontypridd, who beat cup kings Llanelli in Round 4, will be wary of their trip to Division One East club Blackwood.
Konica Minolta Cup Round 5
(Matches to be played on the weekend of February 16th)
Bedwas v Newport
Cross Keys v Newport Saracens
Blackwood v Pontypridd
Aberavon v Cardiff
Ebbw Vale v Tondu
Narberth v Bridgend
Tonmawr v Neath
Bargoed v Glamorgan Wanderers
