Jason Tovey returns to fitness following a thigh strain and new signing Peter Bracken is set to feature.
Adam Jones and Gethin Robinson picked up thigh and shoulder injuries respectively in the Connacht game on Saturday whilst Matthew Watkins is ruled out with a groin strain.
Alex Walker is suffering from a knee injury and back row Grant Webb is unavailable through illness.
Dragons squad for Gloucester
Forwards
Ali McKenzie, Dan Lydiate, Duane Goodfield, Gavin Thomas, Hoani MacDonald, Hugh Gustafson, James Harris, Joe Bearman, Lewis Evans, Luke Charteris (C), Nigel Hall, Peter Bracken, Steve Jones
Backs
Aled Brew, Ashley Smith, Danny Lee, James Arlidge, Jason Tovey, Martyn Thomas,Rhodri Gomer Davies, Richard Fussell, Shaun Connor, Tom Riley, Wayne Evans,Will Harries
