Tries from Gavin Spiller, Marc Jones, Gareth Edwards and Gregg Haines helped The Pitmen pick up their third successive bonus point win and maintain their excellent form.
Elswhere, Ystrad Rhondda beat Treorchy 31-3 to move up to second in the table, with Alex Webber among the scorers.
Ynysybwl crossed over five times to come away 33-12 victors away at Merthyr.
RGC 1404, who had been the league leaders prior to this weekend, were not in action due to a postponement against Tredegar.
In Division Two East, Nelson tightened their hold on the top spot thanks to a rampant 47-8 win over bottom of the table Tylorstown, who are yet to pick up any points.
Meanwhile, Llantwit Fardre bagged their first victory of the season in style as they crushed Rhymney 57-5.
It was a successful weekend for Risca in Division Three East as they cruised to a bonus point win to jump to the top of the table. Danny Williams scored three tries in their 34-6 victory over Croesyceiliog
Previous leaders Caerphilly were knocked off the top-spot after a 53-17 away drubbing at Abertillery BG.
At the other end of the table, Tredegar Ironsides earned their first points of the season in a narrow 24-21 home win against Gwernyfed and move off the bottom.
In Division Four East, Daniel Davies scored a brace of tries to help New Tredegar remain in winning ways and beat Blaina 54-12 while Cilfynydd also made it four wins out of four, overcoming Ynysddu 25-15.
In Division Five East Lee John and Dennis Walker both scored hat tricks for Nantyglo as they breezed past Trinant 63-9.
