Cardiff Blues second row Lou Reed, who was called up to the training squad this week, comes straight into the starting line-up as a direct replacement for Evans with the rest of the Wales matchday 23 remaining as published.
Evans has been excluded in order to give him optimum opportunity to manage his injury.
Whilst he completed training this week, he has not been totally free of pain and with this in mind and after extended discussions between the WRU and his regional medical team, it has been decided to withdraw him from the game in order to seek further investigation and opinion.
A time scale for his absence has not been discussed at this present time.
WALES: Leigh Halfpenny; Alex Cuthbert, Jonathan Davies, Jamie Roberts, Liam Williams; Rhys Priestland, Mike Phillips; Gethin Jenkins, Matthew Rees, Scott Andrews, Lou Reed, Luke Charteris, Aaron Shingler, Sam Warburton ©, Toby Faletau
REPLACEMENTS: Ken Owens, Ryan Bevington, Samson Lee, Ryan Jones, Justin Tipuric, Tavis Knoyle, Dan Biggar, Scott Williams
