Like the Wizards, the Titans won their opening game of the competition last weekend with a 20-3 win over Yorkshire Carnegie in Scarborough.
Last season, the Titans made it out of the Pool stage of the competition for the first time, losing to Bristol in the quarter-finals.
The Wizards and Titans met in the British & Irish Cup during the 2012-13 season, with Rotherham winning 49-7 at home, and 25-21 at the Talbot Athletic Ground.
In the RFU Championship, Rotherham are currently fifth after winning three and losing two of their games this season. Last season they finished 4th in the Championship, but lost to Bristol in the Playoffs.
Whilst Aberavon will be in Rotherham this weekend, Carmarthen are home to Plymouth Albion, while Pontypridd and Cross Keys are away to Connacht and Bedford respectively.
Aberavon: 15 Morgan Williams 14 Aaron Grabham 13 Joe Gage 12 David Evans 11 Stef Andrews 10 Ceiron Thomas 9 David Pritchard; 1 Neil White 2 Ieuan Davies 3 Nicky Thomas 4 Ian Moore 5 Sam Williams 6 Rob Dudley-Jones 7 Nathan Brown 8 Ben Thomas
Replacements: 16 Lee Evans 17 Matthew Jenkins 18 Will Price 19 Gareth Harvey 20 Andrew Gwynne 21 Adam Beard 22 Ryan Harford
