The Quins suffered a 37-17 defeat to Jersey but face another side who lost to Leinster A last week.
Albion’s only change in the backs sees Jake Henry come onto the wing for Lewis Warner who moves into the centre.
In the front row Fijian international Sam Matavesi makes his first start of the season for what will be his 50th appearance for the club. Prop Tom Heard, lock Tom Jubb, and flanker Eoghan Grace, who all came on as replacements last week, are handed starting spots.
The final change sees Ali Bone selected at No 8 replacing Welsh international Rhys Oakley while Canadian international Brett Beukeboom will captain Albion for the first time.
Carmarthen Quins: 15 Steffan Evans 14 Aaron Warren 13 Steffan Hughes 12 Rhys Williams 11 Frazar Climo 10 Josh Lewis 9 Kieran Hardy; 1 Rhys Thomas Darran Harris 3 Peter Edwards 4 Lewis Rawlins 5 Richard Kelly (Capt) 6 Phil Day 7 Will Boyde 8 Rob McCusker
Replacements: 16 Torin Myhill 17 Gethin Robinson 18 Ben Leung 19 Shaun Jones 20 Lee Williams 21 Daniel Jones 22 Iolo Evans
Plymouth Albion: 15 Marc Koteczky, 14 Elliot Clements-Hill, 13 Lewis Warner, 12 Toby Howley-Berridge, 11 Jake Henry, 10 Lawrence Rayner, 9 Josh Davies, 1 Luke Chapman, 2 Sam Matavesi, 3 Tom Heard, 4 Tom Jubb, 5 Brett Beukeboom capt, 6 Rob Langley, 7 Eoghan Grace, 8 Ali Bone
Replacements: 16 Ted Stagg, 17 Dan Pullinger, 18 James Gibbons, 19 Herbie Stupple, 20 Cameron Setter, 21 Pete Homan, 22 Tom Hicks
