The match sees the last two unbeaten sides in this year’s tournament face-off, with England one point clear at the top of the table courtesy of Wales drawing 16-16 with Ireland.
This week in ‘Moments in Time’ we looked back at the last five Welsh victories in England, with Wales coming from behind at half-time to claim victory in the most recent four.
6th February 1988, Five Nations, Twickenham: England 3 Wales 11
A brace of tries from Adrian Hadley were critical in helping Wales to victory, with crossing the whitewash only worth four in this era, rather than five as in the present day.
Wales went on to win the Triple Crown but lost to France, claiming part of the last shared Five Nations title.
11th April 1999, Five Nations (last ever), Wembley: England 31 Wales 32
A 79th-minute try from centre Scott Gibbs denied England the Grand Slam and the last ever Five Nations Championship, which instead went to Scotland.
The match was played at the old Wembley due to building work at the Principality Stadium, and saw Wales complete a dramatic comeback.
The visitors had been 25-18 behind at the interval but a superb performance by Neil Jenkins with the boot kept them in the game.
However, Wales were still 31-25 behind with time running out until centre Gibbs scored, with Neil Jenkins notching conversion to secure victory at the last.
2nd February 2008, 6 Nations, Twickenham: England 19 Wales 26
2nd February 2008 brought Warren Gatland’s first match in charge, and a first win at Twickenham for 20 years, but Wales had been 16-6 down at half-time.
Two tries in three minutes late on from Lee Byrne and Mike Phillips helped Wales win 26-19, and start a run that ended in a Grand Slam.
25th February 2012, 6 Nations, Twickenham: England 12 Wales 19
With the scores locked at 12-12 and just five minutes left, a piece of individual brilliance from Scott Williams proved decisive.
Williams stole the ball, then had the intelligence to kick ahead and the speed to collect it, scoring the only try of the match.
The win helped Wales on their way to an 11th Grand Slam.
26th September 2015, Rugby World Cup 2015 pool match, Twickenham: England 25 Wales 28
A faultless performance by Dan Biggar from the tee, kicking 23 points including 8 from 8, inspired Wales to defeating tournament hosts England.
Wales had found themselves 22-12 behind at the interval, but a try from scrum-half Gareth Davies, combined with the relentless and punishing boot of Biggar enabled the visitors to claim a famous win.
Victory helped Wales qualify from the ‘group of death’, which also contained Australia, before falling just short of defeating South Africa in the quarter-finals.