There were 10 tries from the home side as they added to the misery at The Gnoll, where the Neath fans saw their side lose 80-8 to Llandovery in the Principality Premiership earlier in the month.
Matthew Powell picked up a home hat-trick and there were seven other try scorers. Keys led 45-0 at the break and it didn’t help the visitors’ cause that all 10 tries were converted – seven of them by Owen Howe and three by Ethan Davies.
Davies was also one of the Keys try scorers. Richard Cornock, Scott Matthews, James Leadbeater, Adam Powell, Owain Leonard and Nathan Williams scored the other tries.
Keys will now play Carmarthen Quins in the semi-finals.
SSE Swalec Cup Quarter-Finals – 9 April
Ebbw Vale v Llandovery
Pontypridd v Merthyr (TBC)
SSE Swalec Cup Semi Finals – 16 April
Carmarthen Quins v Cross Keys
Pontypridd / Merthyr v Ebbw Vale / Llandovery