Amos, suffered a shoulder injury in the defeat to Australia and has been released back to the Newport Gwent Dragons.
Giles, who has been an additional player, training alongside the squad since the start of the campaign, is now part of the full squad.
Wales Squad Update: Giles wings in
Wales have called Ospreys wing Keelan Giles into their 2016 Under Armour Series squad after releasing Hallam Amos due to injury.