Scrum-half Lewys Gibby and wing Rhys Harris each helped themselves to four tries apiece with centre Ilan Phillips at the double. Right wing Dean James was also on the scoresheet for the Otters in their 11-try romp.
Outside half Jonathan Rogers kicked seven conversions and full-back Ianto Griffiths two. Kaden Davies scored for Ystalyfera, converted by Cellan Carter-Jones.
Second placed Brecon remain 12 points back with a game after they recorded a 26-17 bonus-point victory over bottom side Tata Steel – who are still yet to win a league match this season. Osian Davies, Sam Jones and Tom Richards were the scorers for Brecon – who were also awarded a penalty try. Dion McIntosh added two conversions.
Dunvant defeated Crymych 36-13, Maesteg Quins got the better of Ammanford 23-17 and Newcastle Emlyn edged out Bonymaen 21-18.
In Championship East, current leaders Cardiff Met racked double figures on their way to a 66-15 defeat of Rumney. Wing Jake Thomas ran in a second half hat-trick with Evan Sheldon, Porter Goodrum, Ardal Yallop, Liam Sullivan, Elijah Evans, Maxime van Hilst and Mike Hansen also on the scoresheet. Vikas Meijer kicked five conversions and Charlie Hancock three.
Bargoed were 36-34 winners at St Peter’s and remain a point behind with two games in hand. Centre Jordan Howells scored twice with Lewis Robey, Keegan Bale and Morgan Powell also scoring. Josh Prosser kicked a penalty and four conversions.
St Peter’s collected two bonus points after they scored five tries of their own with right winger Harry Gimson scoring a hat-trick and left winger Jack Roberts at the double. Outside half Tom Francis kicked three conversions and a penalty.
Bedwas completed a league double over Ystrad Rhondda as they left Gelligaled Park with four more points following a 17-15 win. Dale Rogers and Aaron Billingham bagged Bedwas’ two tries, both converted by James Dixon, who also sent over a penalty.
Tom Stacey and Rhys Dauncey were the hosts’ try scorers. Rhys Truelove added their other five points from the tee.
Matthew McGovern scored twice for Newbridge in their 38-33 success at Treorchy. Sam Watkins, Simon Veall, Luke Morgan and Ieuan Jones were the other Newbridge scorers. Josh Malson kicked four conversions.