Tickets priced at £10 for adults and £5 for U16s will go on sale tomorrow from 10am at the Liberty Stadium Ticket Office and online at www.ospreysrugby.com/buytickets
Personal callers can also purchase from the WRU Ticket Office on Westgate Street between 9.30am and 5.30pm, Monday to Saturday.
Thousands are expected to flock to the home of Welsh rugby to support the Ospreys as two squads packed with world leading international talent going head to head in pursuit of a place in the last four.
Ospreys are advising season members they have until Saturday 18th March to secure their tickets in a reserved area via the Liberty Stadium, after which seats will be release to general sale, on a first come, first served basis.
Likewise, wheelchair users and ambulant supporters can purchase tickets via the Liberty Stadium Ticket Office.
Anyone who has already purchased their quarter-final ticket at the original price will be contacted directly over the next 48 hours to outline the various options available to you. Your seat in the reserved area for best available seats is being held for you.
Premier Club members and anyone with hospitality to the match will also be contact by the Ospreys individually.