Cross Keys, who are currently fourth in the table, have been successful in their last four games and will hope to continue their winning run.
Pontypridd have had a good start to the season with seven bonus point wins out of seven to top the Premiership table.
There is all to play for as the two form teams in the Premiership go head to head in this tie.
Pontypridd last met Cross Keys in the league back in April when they travelled to Pandy Park and came away with a victory by 19-27. Just seven days prior to this game they also played each other in Cardiff Arms Park in the SSE Swalec Cup semi-final. Pontypridd on that occasion were triumphant with a score of 33-17.
Going into their next league game against the Keys, Pontypridd are still without long term injury absentees, prop Pat Palmer recovering from a shoulder operation, and lock Alex Jones with a persistent ankle problem.
Winger Dale Stuckey is also sidelined with a dead leg whilst lock Dan Godfrey is struggling to overcome a virus but hopeful of being declared fit.
Pontypridd: 15.Adam Thomas. 14.Lewis I Williams. 13.Gavin Dacey. 12.Dafydd Lockyer (Capt) 11.Owen Jenkins. 10.Jarrod Evans. 9.Joel Raikes; 1.Chris Phillips. 2.Liam Belcher. 3.Keiron Jenkins. 4.Dan Godfrey / A.N. Other. 5.Chris Dicomidis. 6.Hemi Barnes. 7.Rhys Shellard. 8.Owen Sheppeard.
Subs: 16.Lloyd Williams. 17.Ceri Sweeney. 18.Alex Webber. 19.Ashleigh James. 20.Jake Thomas. 21.Wayne O’Connor. 22.Corey Domachowski. 23.Huw Dowden.
