In the starting XV Alberto Sgarbi, who suffered back problems in the last Six Nations game against Scotland, returns to action, as does winger Andrew Vilk in the backs.
Several new faces feature in the forwards too. Both locks Antonio Pavanello and Corniel Van Zyl will be back, while Ignacio Fernandez Rouyet will be moved to loose-head prop and Lorenzo Cittadini will feature as tight-head.
In the back row, Manoa Vosawai will play as flanker, while Brendan Williams starts from the bench
Benetton Treviso: 15 Luke McLean 14 Michele Sepe 13 Alberto Sgarbi 12 Gonzalo Garcia 11 Andrew Vilk 10 Kristopher Burton 9 Fabio Semenzato; 8 Robert Barbieri 7 Benjamin Vermaak 6 Manoa Vosawai 5 Corniel Van Zyl 4 Antonio Pavanello (captain) 3 Lorenzo Cittadini 2 Leonardo Ghiraldini 1 Ignacio Fernandez Rouyet.
Replacements: 16 Diego Vidal 17 Michele Rizzo 18 Pedro Di Santo 19 Valerio Bernabò 20 Gonzalo Padrò 21 Paul Derbyshire 22 Simon Picone 23 Brendan Williams
Dragons: Martyn Thomas, Will Harries, Adam Hughes, Tom Riley, Aled Brew, Jason Tovey, Wayne Evans, Phil Price, Lloyd Burns, Ben Castle, Luke Charteris (C) Adam Jones, Danny Lydiate, Lewis Evans, Toby Faletau
Replacements
Steve Jones, Hugh Gustafson, Dan Way, Gavin Thomas, Andrew Coombs, Joe Bearman, Jon Evans, Ashley Smith