Second-placed Maesteg are poised to take over if Narberth fail as they go to bottom club Brynmawr, who failed to raise a side for Wednesday’s match at Beddau.
Another top fixture will be at Whitland, where the Borderers face a determined Beddau, inspired by fly half, coach and goalkicking ace Brett Davey.
Bonymaen look to get back to winning weays as they entertain Builth Wells at Parc Mawr and two new clubs to the division will meet as Fleur de Lys entertain Bridgend Athletic for the first time.
Blackwood face Tonmawr, for whom Vaea Poteka is playing well at centre and Llangennech will find Glamorgan Wanderers no easy opponents with Dan Jones and Mark Haywood a good goal-kicking duo for the Cardiff-based Wanderers.