Wales started their RBS 6 Nations campaign with a 21-16 defeat to England in front of a full house in Cardiff on Friday night.An early Rhys Webb try helped Wales to a 16-8 interval lead but the 2008, 2012 and 2013 tournament winners were kept scoreless in the second period as England made amends for their 30-3 mauling at the Millennium Stadium two years ago.