Both sides were beaten in the opening round, the Dragons at home to the Blues and the Ospreys at the Scarlets, and will be looking for a morale booster. Back row man Ben Moa will captain a Dragons side showing five changes for the game against the Blues.
Prop Adam Williams is named in the front row, while lock Joe Cooper is called into the pack alongside back rower George Young. Centre Oli Andrews makes his first start of the campaign while a final change sees Jack Maloney bag a starting spot on the wing.
Wales U18 cap Oliver Burrows was a try scorer for the Ospreys at Parc Y Scarlets in their 22-12 defeat and he is joined by fellow try scorer Kyan Lloyd in the home pack.
Ospreys U18: Teigue Williams; Callum Dodd, Logan Phillips, Joe Hawkins, Josh Carrington; Luca Caplin, Brandon Jones; Cameron Jones, Oliver Burrows, Lewys Jones, Ciaran Davies, Tristan Davies (captain), Jordan Evans, Luke Weaver, Kyan Lloyd
Reps: Lewis Lloyd, Laurence Hyde, James Williams, Ben Snadden, Ciaran Commerford, Elis Horgan. Gregor Divine, Iestyn Morgan
Dragons U18: Evan Gregg; Morgan Mohring, Oli Andrews, Oli Andrew, Jack Maloney; Joe Westwood, Che Hope; Aaron Dowse, Conor Chapman, Adam Williams, Joe Cooper, Joe Peard, George Young, Joe Coope-Franklin, Ben Moa (captain)
Reps: Pacey Smith, Jamie Strachan, Jack Powell, Ben Langdon, Lewis Stansfield, Morgan Lloyd, George Stephens, Hamish Anderson
Dragons U16 Red head to The Gnoll to tackle Ospreys West (kick-off 7.15pm) having fought back to claim a 31-31 draw with Dragons Black in the opening round. The Ospreys U16 East side, who opened with a 26-12 win over Scarlets West, travel to Sardis Road to take on Cardiff Blues U16 North (kick-off 7.15pm)
Ospreys U16 West: Harri Houstan; Kian Abraham, Harvey James, Rowan Lovering, Joe Williams; Rhys Harris, Rhodri Lewis; Iestyn Ohlsen-Jones, Kyle Jones, Morgan James, Josef Meek, Freddie Stevens, David Francis, Caradog Kaniewski, Morgan Morse
Reps: Joe Rees, Leo Woolacott, Lewis Nolan, Liam Edwards, Cameron Scott, Ben Thomas, Owain Green, Will Thomas
Dragons Red U16: Reegan Davies; Reuben McCarthy, Harry Ackerman, Brad Hurter, Ieuan Tovey; Harry Fletcher, Sam Allford; Taran Moa, Sam Reed, Jake Wiensnewski, Evan Fears, Dylan Norman, Connor Mayho, Brad Toy, Oliver Reardon
Reps: Matthew Cotton, Ashton Davies, Marco Testagrossa, Will Gregory, James Trumper, Zack Roberts, Matt Taylor, Ellis Hughes
Ospreys U16 East: Cori Jenkins; Gabe Lacey, TJ Hayden, Gus Patterson, Evan Beach; Samson Lawson, Jac Cross; Ollie Donaghue, Jacob Perkins, Ieuan Bissmire, Lewis Marsh, Ethan Mawr, Rhys Nicolas, Charlie Ashpole, Kian Williams-Jones
Reps: Nicky Stephens, Conner Thomas, Cory James, Dan Groth, Nathan Harris, James Thomas, Ellis Bird, Issac Morgan